Time for a New Monitor? Urine Oxygenation Is Associated with Acute Kidney Injury

NGAL, the New Marker for Acute Kidney Injury

Urine YKL-40 is associated with progressive acute kidney injury or death in hospitalized patients

BACKGROUND A translational study in renal transplantation suggested YKL-40, a chitinase 3-like-1 gene product, plays an important role in acute kidney injury (AKI) and repair, but data are lacking about this protein in urine from native human kidneys. METHODS This is an ancillary study to a single-center, prospective observational cohort of patients with clinically-defined AKI according to AK...

Renal oxygenation in clinical acute kidney injury

Renal oxygenation is defi ned as the relationship between renal oxygen delivery (DO 2) and renal oxygen consumption (VO 2) and it can easily be shown that the inverse of this relationship is equivalent to renal extraction of O 2 (O 2 Ex). An increase in renal O 2 Ex means that renal DO 2 has decreased in relation to renal VO 2 , i. e., renal oxyge-nation is impaired, and vice versa. When compar...

Correction: Urine neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute canine kidney injury

After the publication of this work [1], we became aware of the fact that the values of NGAL reported in this study were concentrations of diluted clinic samples; and therefore for the actual concentration of urine NGAL, the value should multiply the dilution factor. With exception of Figure three (Figure 1 here), all the values of urine NGAL described in this study were detected by in-house ELI...

Urine neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute canine kidney injury

BACKGROUND Biomarkers for the early prediction of canine acute kidney injury (AKI) are clinically important. Recently, neutrophil gelatinase-associated lipocalin (NGAL) was found to be a sensitive biomarker for the prediction of human AKI at a very early stage and the development of AKI after surgery. However, NGAL has not yet been studied with respect to dog kidney diseases. The application of...